Shigeharu Wakana Selected Research

Torrance Type Platyspondylic Lethal Skeletal Dysplasia

12/2015	Endoplasmic reticulum stress-mediated apoptosis contributes to a skeletal dysplasia resembling platyspondylic lethal skeletal dysplasia, Torrance type, in a novel Col2a1 mutant mouse line.
6/2011	ENU-induced missense mutation in the C-propeptide coding region of Col2a1 creates a mouse model of platyspondylic lethal skeletal dysplasia, Torrance type.

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Shigeharu Wakana Research Topics

Disease

3	Neoplasms (Cancer) 01/2016 - 10/2014
2	Nervous System Diseases (Neurological Disorders) 01/2020 - 12/2016
2	Neurodevelopmental Disorders 01/2020 - 02/2012
2	Insulin Resistance 01/2016 - 04/2005
2	Torrance Type Platyspondylic Lethal Skeletal Dysplasia 12/2015 - 06/2011
2	Schizophrenia (Dementia Praecox) 12/2014 - 02/2012
2	Carcinogenesis 10/2014 - 11/2012
1	Hypochromic Anemia (Chlorosis) 11/2022
1	Priapism 01/2022
1	Leukoencephalopathies 01/2020
1	Autism Spectrum Disorder 01/2020
1	Intellectual Disability (Idiocy) 01/2020
1	Epilepsy (Aura) 12/2019
1	Glut1 Deficiency Syndrome 12/2019
1	Skin Neoplasms (Skin Cancer) 11/2017
1	Sleep Deprivation 11/2016
1	Carcinoma (Carcinomatosis) 01/2016
1	Dermatitis 01/2016
1	Persistent Hyperplastic Primary Vitreous 01/2016
1	Darier Disease (Darier's Disease) 01/2016
1	Obesity 01/2016
1	Weight Gain 03/2015
1	Body Weight (Weight, Body) 03/2015
1	Gardner Syndrome 07/2013
1	Pulmonary Alveolar Proteinosis 01/2013
1	Male Infertility (Male Sterility) 01/2013
1	Liver Diseases (Liver Disease) 01/2013
1	Emphysema 01/2013
1	Mental Disorders (Mental Disorder) 02/2012
1	Inflammation (Inflammations) 04/2010
1	Fibrosarcoma 04/2010
1	Retinal Degeneration 03/2010
1	Pathologic Processes 12/2009
1	Osteoarthritis 10/2007
1	Amelogenesis Imperfecta 03/2005
1	Type 2 Maturity-Onset Diabetes of the Young 06/2004
1	Hyperglycemia 06/2004
1	Lymphoma (Lymphomas) 01/2004
1	Deafness (Deaf Mutism) 03/2003
1	Breast Neoplasms (Breast Cancer) 09/2002
1	Cardiomegaly (Heart Hypertrophy) 09/2002
1	Fatty Liver 09/2002

Drug/Important Bio-Agent (IBA)

7	Ethylnitrosourea (N-Ethyl-N-nitrosourea)IBA 11/2022 - 03/2010
7	Proteins (Proteins, Gene)FDA Link 12/2019 - 03/2003
3	Glucose (Dextrose)FDA LinkGeneric 12/2019 - 03/2015
2	DNA Transposable Elements (Element, IS)IBA 01/2020 - 12/2016
2	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 01/2016 - 09/2002
2	Retinaldehyde (Retinal)IBA 01/2016 - 03/2010
2	EnzymesIBA 01/2013 - 06/2004
1	Ferritins (Ferritin)IBA 11/2022
1	Heme (Haem)IBA 11/2022
1	Phospholipids (Phosphatides)FDA LinkGeneric 01/2022
1	Eukaryotic Initiation Factor-2B (Eukaryotic Initiation Factor 2B)IBA 01/2020
1	Peptide Initiation Factors (Initiation Factor)IBA 01/2020
1	Eukaryotic Initiation Factor-2 (EIF 2)IBA 01/2020
1	Facilitative Glucose Transport Proteins (Glucose Transporter)IBA 12/2019
1	Phosphotransferases (Kinase)IBA 11/2016
1	Calcium-Transporting ATPases (Ca2+ ATPase)IBA 01/2016
1	Peptide Hydrolases (Proteases)FDA Link 01/2016
1	Nonsense Codon (Nonsense Mutation)IBA 01/2016
1	Adenosine Triphosphatases (ATPase)IBA 01/2016
1	Ointments (Pastes)IBA 01/2016
1	NeuropeptidesIBA 01/2016
1	Mutant Proteins (Protein, Mutant)IBA 12/2015
1	Insulin (Novolin)FDA Link 03/2015
1	Pharmaceutical PreparationsIBA 03/2015
1	Retroelements (Retrotransposon)IBA 12/2014
1	Retinoblastoma ProteinIBA 10/2014
1	LipidsIBA 01/2013
1	Surface-Active Agents (Surfactants)IBA 01/2013
1	Pulmonary Surfactant-Associated Protein D (Surfactant Protein D)IBA 01/2013
1	Phytanic AcidIBA 01/2013
1	PhytolIBA 01/2013
1	9,10-Dimethyl-1,2-benzanthraceneIBA 11/2012
1	Amino Acids FDA Link 02/2012
1	Methylphenidate (Ritalin)FDA LinkGeneric 02/2012
1	Collagen Type II (Type II Collagen)IBA 06/2011
1	CytokinesIBA 04/2010
1	MethylcholanthreneIBA 04/2010
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 04/2010
1	Reactive Oxygen Species (Oxygen Radicals)IBA 04/2010
1	Calcium-Independent Phospholipases A2IBA 12/2009
1	Phospholipases (Phospholipase)IBA 12/2009
1	CalciumIBA 12/2009
1	Factor V (Coagulation Factor V)IBA 10/2007
1	Insulin ReceptorIBA 04/2005
1	tuftelin (enamelin)IBA 03/2005
1	GlucokinaseIBA 06/2004
1	Alkylating AgentsIBA 01/2004
1	Methylnitrosourea (N-Methyl-N-nitrosourea)IBA 01/2004
1	Carnitine (L-Carnitine)FDA LinkGeneric 09/2002
1	Messenger RNA (mRNA)IBA 09/2002
1	Nuclear Proteins (Protein, Nuclear)IBA 09/2002

Therapy/Procedure

1	Therapeutics 11/2017
1	Subcutaneous Injections 04/2010